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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Fibroblast growth factor 19 (FGF19)

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Contents

FGF19/15 then enters the portal circulation to activate the fibroblast growth factor receptor 4/bKlotho complex in hepatocytes, which activates the extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase 1/2 signaling pathways to inhibit gene expression in Classic way of BA synthesis.
Taylor et al. 2022 Drug Metab Dispos 50: 456-467

Fibroblast growth factor 19 (FGF19) is the human orthologue of mouse FGF15
Li & Chiang 2020 Hepatobiliary Surg. Nutr. 9: 15…

References (Sources)

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease
Li & Chiang 2020 Hepatobiliary Surg. Nutr. 9: 152-169
Review
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
Song et al. 2009 Hepatology 49: 297-305
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
Holt et al. 2003 Genes Dev 17: 1581-91
Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
Taylor et al. 2022 Drug Metab Dispos 50: 456-467
Review
NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
Harrison et al. 2018 The Lancet 391: 1174-1185
Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19
Zhou et al. 2014 Cancer Res 74: 3306-16.
Soluble expression of disulfide bond containing proteins FGF15 and FGF19 in the cytoplasm of Escherichia coli
Kong & Guo 2014 PLoS One 9: e85890

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FGF19 - Wikipedia