Fibroblast growth factor 19 (FGF19)

FGF19/15 then enters the portal circulation to activate the fibroblast growth factor receptor 4/bKlotho complex in hepatocytes, which activates the extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase 1/2 signaling pathways to inhibit gene expression in Classic way of BA synthesis.
Taylor et al. 2022 Drug Metab Dispos 50: 456-467

Fibroblast growth factor 19 (FGF19) is the human orthologue of mouse FGF15
Li & Chiang 2020 Hepatobiliary Surg. Nutr. 9: 152-169

A nontumorigenic FGF19 analogue NGM282 has been developed that retained the signaling property in regulating bile acid synthesis and improving hepatic steatosis without exhibiting tumorigenic effect
Wu et al. 2010 Proc Natl Acad Sci U S A 107: 14158-63
Zhou et al. 2014 Cancer Res 74: 3306-16
Harrison et al. 2018 The Lancet 391: 1174-1185

FGF19 binds to FGFR4 on hepatocytes
Schubert et al. 2017 Immunological Reviews 279: 23-35

Studies have shown that Fibroblast growth factor 19 (FGF19) treatment rapidly repressed CYP7A1 mRNA within 2 h of treatment initiation
Potthoff et al. 2011 Cell Metab 13: 729-38
Kong et al. 2012 Hepatology 56: 1034-43
Kong & Guo 2014 PLoS One 9: e85890

Studies in animal models have shown that Fibroblast growth factor 19 (FGF19) promote liver cancer, which raised concerns for its use in treating chronic diseases
Nicholes et al. 2002 Am J Pathol 160: 2295-307
Sawey et al. 2011 Cancer Cell 19: 347-58
Zhou et al. 2014 Cancer Res 74: 3306-16

In the small intestine , FXR induces FGF19 transcription in humans and FGF15 in mice
Holt et al. 2003 Genes Dev 17: 1581-91
Song et al. 2009 Hepatology 49: 297-305

Fibroblast growth factor 19 (FGF19) binds FGFR4 to repress CYP7A1 gene transcription
Holt et al. 2003 Genes Dev 17: 1581-91
Song et al. 2009 Hepatology 49: 297-305