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Occludin
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Contents
Occludin plays a role in the formation and disassembly of the Tight Junction proteins and is involved in the regulation of the “leak pathway” or paracellular flux of large molecules (1, 15–17)
Kaminsky et al. 2021 Front. Immunol. 12: 767456 (1, 5, 12–14).
Among these TJ proteins, occludin always combines with the zonula occludens members ZO-1 / ZO-2 or ZO-1 / ZO-3 in the cell membrane (7).
Su et al. 2021 Inflamm Bowel Dis. 27: 1302
Occludin is also involved in the stability and regulation of Tight-Junction Molecules / Tight Junction Proteins
Occludin plays a role in the formation and disassembly of the [TJ](brain://HWvzcrmAmk67gHnHgflHkw/Tigh…
References (Sources)
- A Porous Defense: The Leaky Epithelial Barrier in Intestinal Disease
- An Intestinal Paracellular Pathway Biased Toward Positively-Charged Macromolecules
- Molecular Physiology and Pathophysiology of Tight Junctions. IV. Regulation of Tight Junctions by Extracellular Stimuli: Nutrients, Cytokines, and Immune Cells
- Occludin OCEL-Domain Interactions are Required for Maintenance and Regulation of the Tight Junction Barrier to Macromolecular Flux
- Occludin Regulates Macromolecule Flux Across the Intestinal Epithelial Tight Junction Barrier
- Occludin: A Novel Integral Membrane Protein Localizing At Tight Junctions
- Tight Junction Pore and Leak Pathways: A Dynamic Duo