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Occludin plays a role in the formation, disassembly and stability of the Tight Junction proteins and is involved in the regulation of the “leak pathway” or paracellular flux of macromolecules across the Intestinal Epithelial Tight Junction Barrier. Occludin OCEL-domain interactions are required for that (1, 2, 3, 4, 5, 6, 7, 8, 10).
Among these TJ proteins, occludin always combines with the zonula occludens members Zonula Occludens Protein-1 (ZO-1) / Zonula Occludens Protein-2 (ZO-2) or [Zonula Occlud…