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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Eosinophilic esophagitis (EoE)

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Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus, prevalent in 26 to 60 cases per 100,000 individuals in North America
Navarro et al. 2019 Aliment Pharmacol Ther 49(9): 1116-1125
Hahn et al. 2023 Clin Gastroenterol Hepatol 21(13): 3270-3284

Symptoms evolve with age, starting with feeding difficulties in early life and progressing to reflux, dysphagia, and food impaction in older individuals. Diagnosis requires clinical symptoms and 15+ eosinophils per high power field in biopsies
Aceves et al. 2023 Ann Allergy Asthma Immunol 130(3): 371-378

Non-IgE mediated food allergies, such a…

References (Sources)

Clinical guidance for the use of dupilumab in eosinophilic esophagitis: a yardstick
Aceves et al. 2023 Ann Allergy Asthma Immunol 130(3): 371-378
Comparison of atopic features between children and adults with eosinophilic esophagitis
Vernon et al. 2014 Allergy Asthma Proc 35(5): 409-414
Dupilumab in adults and adolescents with eosinophilic esophagitis
Dellon et al. 2022 N Engl J Med 387(25): 2317-2330
Eosinophilic esophagitis: a review
Muir & Falk 2021 JAMA 326(13): 1310-1318
Review
Global incidence and prevalence of eosinophilic esophagitis, 1976–2022: a systematic review and meta-analysis
Hahn et al. 2023 Clin Gastroenterol Hepatol 21(13): 3270-3284
Meta-Analysis
Review
Pathophysiology of non-IgE-mediated food allergy
Zhang et al. 2021 Immunotargets Ther 10: 431-446
Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies
Navarro et al. 2019 Aliment Pharmacol Ther 49(9): 1116-1125
Meta-Analysis
Review

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