Septicemia / Sepsis

Sepsis follows a cytokine storm with hyper inflammation and protracted immunosuppression.
Hotchkiss & Opal 2020 N Engl J Med 382: 1270-1272

Sepsis is characterized by colonization with multidrug-resistant healthcare-associated pathogens.
Kim et al. 2020l Nat Commun. 11(1): 2354

Sepsis is caused by many organisms including bacteria, viruses and fungi
Sehgal et al. 2020 Hospital Pediatrics 10(12): 1021–1030

One of the pathologic hallmarks of sepsis is the excessive activation of the immune and coagulation systems by pathogens, particularly bacteria (>/= 80%)
Gando et al. 2016 Nat. Rev. Dis. Primers 2: 16037
Hotchkiss et al. 2016 Nat. Rev. Dis. Primers 2: 16045

Sepsis is a serious condition where the body's response to an infection causes organ dysfunction and can be life-threatening. It is triggered by microbial dissemination via the bloodstream and a systemic inflammatory response
Singer et al. 2016 JAMA 315: 801–810

Although fungal sepsis is less frequent, invasive fungal infections have particularly high mortality rates
Wisplinghoff et al. 2004 Clin. Infect. Dis. 39: 309–317
Brown et al. 2012 Sci. Transl. Med. 4: 165rv13

Common locations for the primary infection include the lungs, brain, urinary tract, skin, and abdominal organs
Jui et al. 2011 American College of Emergency Physicians. In Tintinalli JE, Stapczynski JS, Ma OJ, Cline DM, Cydulka RK, Meckler GD (eds.). Tintinalli's Emergency Medicine: A Comprehensive Study Guide (7th ed.). New York: McGraw-Hill. pp. 1003–14 ISBN 9780071484800.

see also:
Bacteremia / Bloodstream infections
Candida albicans / Candida albicans infection
Pathogenicity & Staphylococcus aureus