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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Septicemia / Sepsis

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Sepsis follows a cytokine storm with hyper inflammation and protracted immunosuppression.
Hotchkiss & Opal 2020 N Engl J Med 382: 1270-1272

Sepsis is characterized by colonization with multidrug-resistant healthcare-associated pathogens.
Kim et al. 2020l Nat Commun. 11(1): 2354

Sepsis is caused by many organisms including bacteria, viruses and fungi
Sehgal et al. 2020 Hospital Pediatrics 10(12): 1021–1030

One of the pathologic hallmarks of sepsis is the excessive activation of the immune and coagulation systems by pathogens, particularly bacteria (>/= 80%)
Gando et al. 2016 Nat. Rev. Dis. Primers 2: 16037
Hotchkiss et al. 2016 Nat. Rev. Dis. Primers 2: 16045

Sepsis is a serious condition whe…

References (Sources)

ACE2 shedding exacerbates sepsis‑induced gut leak via loss of microbial metabolite 5‑methoxytryptophan
Gong et al. 2025 Microbiome 13: 136
Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
Rudd et al. 2020
Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults
Kalantar et al. 2022 Nat Microbiol 7: 18051816
qSOFA does not predict bacteremia in patients with severe manifestations of sepsis
Cheng et al. 2022 J Assoc Med Microbiol Infect dis Can 7: 364-368
Sepsis From the Gut: The Enteric Habitat of Bacteria That Cause Late-Onset Neonatal Bloodstream Infections
Carl et al. 2014 Clin Infect Dis 58: 1211-1218
STING-mediated intestinal barrier dysfunction contributes to lethal sepsis
Hu et al. 2019 EBioMedicine 41: 497–508
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Rhodes et al. 2017 Intensive Care Med 43: 304-377

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