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Septicemia / Sepsis
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Contents
Sepsis follows a cytokine storm with hyper inflammation and protracted immunosuppression.
Hotchkiss & Opal 2020 N Engl J Med 382: 1270-1272
Sepsis is characterized by colonization with multidrug-resistant healthcare-associated pathogens.
Sepsis is caused by many organisms including bacteria, viruses and fungi
One of the pathologic hallmarks of sepsis is the excessive activation of the immune and coagulation systems by pathogens, particularly bacteria (>/= 80%)
Gando et al. 2016 Nat. Rev. Dis. Primers 2: 16037
Sepsis is a severe, life-threaten…
References (Sources)
- Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
- Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults
- qSOFA does not predict bacteremia in patients with severe manifestations of sepsis
- Sepsis From the Gut: The Enteric Habitat of Bacteria That Cause Late-Onset Neonatal Bloodstream Infections
- STING-mediated intestinal barrier dysfunction contributes to lethal sepsis
- Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
- TMEM173 Drives Lethal Coagulation in Sepsis