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Heart diseases

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Abnormal calcium signaling between organelles such as the sarcoplasmic reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium serves as a secondary messenger mediating inter-organellar crosstalk, essential for maintaining the cardiomyocyte function.
Hulsurkar et al. 2022 Expert Opinion on Therapeutic Targets 26(4): 303-317