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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Cancer / Tumors & High-fat diet (HFD)

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Over-consumption of High-fat diet (HFD) directly promotes Carcinogenesis / Oncogenesis / Tumorigenesis](brain://sbwY2i5c3lawYThcRK42CQ/KarzinogenesecarcinogenesisgenotoxicityCancerogenesisTumorigenesis), such as Prostate cancer, Colorectal Cancer (CRC) and Hepatocellular Carcinoma (HCC)
Beyaz et al. 2016 Nature 531: 53–58
Labbe et al. 2019 Nat. Commun. 10:4358
Yang et al. 2022h Gastroenterology 162: 135–149

A better strategy is a diet that is low in glucose but has normal caloric value…

Dietary modifications for enhanced cancer therapy
Kanarek et al. 2020 Nature 579: 507-517
Review
Frontline Science: high fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells
Clements et al. 2018 J. Leukoc. Biol. 103: 395–407
High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model
Chen et al. 2007a Cancer Sci. 98: 1683-8
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Beyaz et al. 2016 Nature 531: 53–58
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Labbe et al. 2019 Nat. Commun. 10:4358
High-fat diet promotes colorectal tumorigenesis through modulating gut microbiota and metabolites
Yang et al. 2022h Gastroenterology 162: 135–149

12/16/2025