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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Arrestins

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Contents

Arrestins bind to receptors and block G-protein coupling.
Stadel et al. 1983 Proc Natl Acad Sci USA 80: 3173-3177
Pitcher et al. 1992 Biochemistry 31: 3193–3197
Pitcher et al. 1998 Annu Rev Biochem 67: 653-692
Krupnick & Benovic 1998 Annu Rev Pharmacol Toxicol 38: 289-319

Arrestins help with receptor internalization using clathrin-mediated endocytosis. Arrestins interact with clathrin and AP2 adaptor complex
Goodman Jr et al. 1996 Nature 383: 447-450
Laporte et al. 1999 Proc Natl Acad Sci USA 96: 3712-3717

Receptors in clathrin-coated pits undergo endocytosis in a dynamin-dependent process
Do…

References (Sources)

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor
Goodman Jr et al. 1996 Nature 383: 447-450
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor
Stadel et al. 1983 Proc Natl Acad Sci USA 80: 3173-3177
Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMPdependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms
Pitcher et al. 1992 Biochemistry 31: 3193–3197
G protein-coupled receptor kinases
Pitcher et al. 1998 Annu Rev Biochem 67: 653-692
Review
Mechanisms of endocytosis
Doherty & McMahon 2009 Annu Rev Biochem 78: 857-902
Review
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
Laporte et al. 1999 Proc Natl Acad Sci USA 96: 3712-3717
The role of receptor kinases and arrestins in G protein-coupled receptor regulation
Krupnick & Benovic 1998 Annu Rev Pharmacol Toxicol 38: 289-319
Review

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Arrestin - Wikipedia