Arrestins

Arrestins bind to receptors and block G-protein coupling.
Stadel et al. 1983 Proc Natl Acad Sci USA 80: 3173-3177
Pitcher et al. 1992 Biochemistry 31: 3193–3197
Pitcher et al. 1998 Annu Rev Biochem 67: 653-692
Krupnick & Benovic 1998 Annu Rev Pharmacol Toxicol 38: 289-319

Arrestins help with receptor internalization using clathrin-mediated endocytosis. Arrestins interact with clathrin and AP2 adaptor complex
Goodman Jr et al. 1996 Nature 383: 447-450
Laporte et al. 1999 Proc Natl Acad Sci USA 96: 3712-3717

Receptors in clathrin-coated pits undergo endocytosis in a dynamin-dependent process
Doherty & McMahon 2009 Annu Rev Biochem 78: 857-902

Receptors then reach early endosomes. Caveolin-mediated endocytosis also plays a role. In endosomes, receptors have two paths. They recycle back to the cell surface. Or, they go to lysosomes for degradation. This affects receptor downregulation
Krupnick & Benovic 1998 Annu Rev Pharmacol Toxicol 38: 289-319
Pitcher et al. 1998 Annu Rev Biochem 67: 653-692

These processes are linked. They regulate GPCR signaling location and duration.
Calebiro et al. 2025 Trends in Biochemical Sciences 50(1): 46

see also:
G-protein coupled receptors (GPCRs)
G-protein-coupled receptor kinases (GRKs)
Receptor-mediated endocytosis