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Inhibiting Glycogen synthase kinase 3 (GSK-3) activity can significantly enhance the generation of human IL-10+ CD4+ CD25+ FOXP3 high Treg (peripherally induced)
IL-10+ CD4+ CD25+ FOXP3 high Treg (peripherally induced), which are induced by inhibiting GSK3, exhibit the typical features of immune-suppressive T cells. Our research shows that these IL-10+ iTregs have an improved ability to suppress, functioning through mechanisms that depend on Interleukin-10 (IL-10) as well as those that do not. Interestingly, the …