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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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IkB kinase (IKK)

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The IkB kinase (IKK) complex consists of the catalytic kinases IKK alfa and IKK beta and the regulatory subunit IKK gamma (NEMO)
Oeckinghaus et al. 2011 Nat Immunol 12(8): 695-708
Zhang et al. 2017a Cell 168(1-2): 37-57

In the canonical (classical) pathway, degradation of the inhibitory IkB protein occurs following phosphorylation of the IkB kinase (IKK) complex
Oeckinghaus et al. 2011 Nat Immunol 12(8): 695-708
Zhang et al. 2017a Cell 168(1-2): 37-57

Phosphorylated IkB kinase (IKK) is ubiquitinated and degraded by the proteasome, which allows [NFKB p50/p65 Heterodim…

References (Sources)

30 Years of NF-kb: A Blossoming of Relevance to Human Pathobiology
Zhang et al. 2017a Cell 168(1-2): 37-57
Crosstalk in NF-kb Signaling Pathways
Oeckinghaus et al. 2011 Nat Immunol 12(8): 695-708
Innate Immunity
Hoffmann & Akira 2013 Current Opinion in lmmunology 25: 1-3

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IkB kinase (IKK)

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