IkB kinase (IKK)

The IkB kinase (IKK) complex consists of the catalytic kinases IKK alfa and IKK beta and the regulatory subunit IKK gamma (NEMO)
Oeckinghaus et al. 2011 Nat Immunol 12(8): 695-708
Zhang et al. 2017a Cell 168(1-2): 37-57

In the canonical (classical) pathway, degradation of the inhibitory IkB protein occurs following phosphorylation of the IkB kinase (IKK) complex
Oeckinghaus et al. 2011 Nat Immunol 12(8): 695-708
Zhang et al. 2017a Cell 168(1-2): 37-57

Phosphorylated IkB kinase (IKK) is ubiquitinated and degraded by the proteasome, which allows NFKB p50/p65 Heterodimers to translocate from the cytoplasm to the nucleus to activate the inflammatory genes
Oeckinghaus et al. 2011 Nat Immunol 12(8): 695-708
Zhang et al. 2017a Cell 168(1-2): 37-57

IkB is destroyed by the 26S proteasome
Hoffmann & Akira 2013 Current Opinion in lmmunology 25: 1-3