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CD96 is a novel target for cancer immunotherapy
Blockade of CD96 suppresses primary tumor growth in mice in a CD8 + T cell-dependent manner.
CD96 is expressed on CD8 + T lymphocytes in tumors together with PD-1.
The combination of anti-CD96 with anti-PD-1 increased the percentage of IFNγ-expressing CD8 + T lymphocytes.
CD96 is an immune checkpoint on CD8+ T cells. Blockading it, in combination with blocking other immune checkpoints, is a strategy to increase T cell activity and suppress tumor growth.
see also:
[CD8+ mediated…