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Activating transcription factor 3 (ATF3) is an essential regulator of follicular helper T (TFH ) cells in the gut and its sIgA production.
Cao et al. 2020a J Immunol 205: 842
In the intestine, induction of ATF3 can prevent the development of colitis by facilitating the development of follicular helper T cells and microbiota homeostasis (Cao et al., 2019, 2020).
ATF3 deficiency in CD4 + T cells impaired the development of gut TFH cells and therefore diminished sIgA production
Cao et al. 2020a J Immunol 205: 842…