Endometrial Cancer (EC)

Endometrial cancer (EC) is the most common gynecologic malignancy in high-income countries, and its incidence is increasing worldwide. The American Cancer Society estimates that there will be over 65,950 new cases diagnosed in 2022 in the US.
Crosbie et al. 2022 The Lancet 399: 1412-1428
Halla 2022 J Adv Pract Oncol 13(1): 45-59
Mutlu et al. 2022 Expert Review of Anticancer Therapy 22(3): 249-258

The growing prevalence of obesity is the leading cause.
Crosbie et al. 2022 The Lancet 399: 1412-1428

• The diagnosis of endometrial carcinoma is currently based on morphology and immunohistochemistry.


• However, there is significant variability in diagnosis, particularly with high-grade endometrial carcinomas.


• This review aims to provide an update on the molecul…