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Major Depressive Disorder (MDD) involves complex neurobiological and peripheral mechanisms, such as altered neurotransmission (1, 2, 3, 4), HPA axis dysregulation (5), and systemic inflammation (6). Standard treatments often do not achieve full remission (7) and have high recurrence rates, highlighting the need for new therapeutic strategies. Also known as clinical depression or major depression, it is a debilitating condition characterized by altered mood, impaired cognitive functions, anhedonia (the inability to feel pleasure), and vegetative disorders like insomnia, fatigue, or [anorexia]…