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Gamma Delta T Cells
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Effective molecules: Interleukin-17 Family / Interleukin-17 (IL-17)
Like tissue-resident myeloid cells (such as macrophages), fetal Gamma Delta T Cells are often found in tissues rather than circulating in the blood. They can populate various organs during fetal development and remain there as part of the tissue-resident immune system.
Two distinct subsets of gamma-delta T-lymphocytes provide two critical cytokines, interferon-gamma (IFN-gamma) and interleukin-17A (IL-17)
Gamma Delta T Cells are innate immune cells with strong cytotoxicity as well as the capacity to secrete…
References (Sources)
- From thymus to periphery: Molecular basis of effector gamma delta ‐T cell differentiationReview
- IFNγ-Producing γ/δ T Cells Accumulate in the Fetal Brain Following Intrauterine Inflammation
- Profiles, Distribution, and Functions of Gamma Delta T Cells in Ocular Surface Homeostasis and Diseases
- Stimulation of Human gamma/delta T Cells by Nonpeptidic Mycobacterial Ligands
- The burgeoning family of unconventional T cells
- Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell
- γδ T cells in tissue physiology and surveillance