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Gemcitabine is frequently utilized in the treatment of pancreatic ductal adenocarcinoma (PDAC). Its antitumor efficacy is attributed to the processes of intracellular activation and degradation. The active metabolites, gemcitabine diphosphate and triphosphate, play crucial roles by inhibiting ribonucleotide reductase and DNA synthesis, respectively, which ultimately results in the death of cancer cells. The primary enzyme responsible for the inactivation of gemcitabine is cytidine deaminase (CDD)
![Gemcitabine](.data/md-im…