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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Clostridioides difficile infection (CDI) (recurrent) & Drugs/Treatments

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Considerable progress has been made in the development of new anti-CDI drug candidates. Nevertheless, a greater comprehension of Clostridioides difficile infection (CDI) pathogenesis and host-microbe interactions is beginning to uncover potential novel therapeutic targets, which can be exploited to plug gaps in the Clostridioides difficile infection (CDI)(brain://bQ4LAx9Ly0u1JoYHsdVoaQ/ClostridioidesDifficileInfectionCdi) drug discovery pipeline.
Monaghan et al. 2021 Expert Opinion on Therapeutic Targets 25(11): 949-963

Add-on treatment with Fructooligosaccharides (FOS), NTCD-M3 spores, [Rifaximin](brain://IdbSeeka1kSQbdBQ3qPsaw/Rifax…

References (Sources)

Advancing therapeutics for recurrent clostridioides difficile infections: an overview of vowst's FDA approval and implications
Jain et al. 2023 Gut Microbes 15(1): 2232137
Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
McDonald et al. 2018 Clin Infect Dis 66: 987–94.
Effect of fecal microbiota transplantation on recurrence in multiply recurrent Clostridium difﬁcile infection: A randomized trial
Kelly et al. 2016 Ann Intern Med 165: 609-616
Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: a systematic review and meta-analysis.
Ianiro et al. 2018 United European Gastroenterol J 6: 1232-44
Faecal microbiota transplantation for recurrent Clostridioides difﬁcile infection: an updated systematic review and meta-analysis
Baunwall et al. 2020 EClinicalmedicine 29–30: 100642
Meta-Analysis
Review
Investigational drug therapies currently in early-stage clinical development for the treatment of clostridioides (clostridium) difficile infection
Tran et al. 2019 Expert Opin. Investig. Drugs 28: 323-335
Review
Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection
Weingarden et al. 2014 Am J Physiol Gastrointest Liver Physiol 306: G310–19

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5/29/2026

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