meRfi®-GM
Clostridioides difficile infection (CDI) (recurrent) & Drugs/Treatments
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Contents
Considerable progress has been made in the development of new anti-CDI drug candidates. Nevertheless, a greater comprehension of Clostridioides difficile infection (CDI) pathogenesis and host-microbe interactions is beginning to uncover potential novel therapeutic targets, which can be exploited to plug gaps in the Clostridioides difficile infection (CDI)(brain://bQ4LAx9Ly0u1JoYHsdVoaQ/ClostridioidesDifficileInfectionCdi) drug discovery pipeline.
Narrow-spectrum antibiotics have shown improved efficacy, but [fecal microbiota transplant (FMT) is highly effective in preventing rCDI](brain…
References (Sources)
- Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
- Effect of fecal microbiota transplantation on recurrence in multiply recurrent Clostridium difficile infection: A randomized trial
- Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: a systematic review and meta-analysis.
- Faecal microbiota transplantation for recurrent Clostridioides difficile infection: an updated systematic review and meta-analysis
- Investigational drug therapies currently in early-stage clinical development for the treatment of clostridioides (clostridium) difficile infection
- Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection
- Randomised clinical trial: faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent Clostridium difficile infection