Inflammatory Bowel Disease (IBD) & Oxidative Stress / Reactive Oxygen Species (ROS)

Oxidative Stress / Reactive Oxygen Species (ROS) plays a crucial role in the development and progression of Inflammatory Bowel Disease (IBD), with reactive oxygen species being key contributors to the pathology
Miranda et al. 2023 Oxygen 3(3): 336-365
Sahoo et al. 2023 Front Endocrinol (Lausanne) 14: 1217165

Inflammatory reactions in the gut result in excessive production of reactive oxygen species (ROS). This overproduction of ROS can damage intestinal epithelial cells, disrupt mucosal barrier function, activate pro-inflammatory signaling pathways, and alter the gut microbiota.
The interplay between oxidative stress and inflammation creates a vicious cycle that maintains and worsens the symptoms of IBD.
Sahoo et al. 2023 Front Endocrinol (Lausanne) 14: 1217165

see also:
Oxidative Stress / Reactive Oxygen Species (ROS)