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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Barrier Permeability / Intestinal Permeability & High-fat Diet (HFD)

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A high-fat diet (HFD) significantly alters the expression of tight junction proteins, such as Zonula Occludens Protein-1 (ZO-1), occludin, and claudin-1. These proteins are crucial for maintaining intestinal barrier integrity, and their disruption leads to increased permeability.
Rohr et al. 2020
Lombardo et al. 2024 Food Funct. 15(19): 9941-9953

HFD triggers inflammation by enhancing [Human Cytokine Production…

A flavonoid-rich extract of bergamot juice improves high-fat diet-induced intestinal permeability and associated hepatic damage in mice
Lombardo et al. 2024 Food Funct. 15(19): 9941-9953
Effects of dietary fat profile on gut permeability and microbiota and their relationships with metabolic changes in mice.
Lam et al. 2015 Obesity 23: 1429-39
Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review
Rohr et al. 2020
Review

5/29/2026