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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Metronidazole & Bacterial vaginosis

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The standard first-line therapy with metronidazole (MTZ) is successful in some cases of bacterial vaginosis (BV), but over 50% of patients experience a recurrence within a year.
Bradshaw et al. 2006 J Infect Dis 193: 1478-1486
Cohen et al. 2020 NEJM 382: 1906-1915
Schwebke et al. 2021 Clin Infect Dis 73: e672-e679

Possibly, the reason for frequent recurrence could be the shift of the FGT microbiome towards Lactobacillus iners dominance instead of a Lactobacillus crispatus dominance due to Metronidazole
Srinivasan et al. 2010 PLoS ONE 5: e10197
Mitche…

References (Sources)

Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis
Ravel et al. 2013 Microbiome 1: 29
High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
Bradshaw et al. 2006 J Infect Dis 193: 1478-1486
Impact of oral metronidazole treatment on the vaginal microbiota and correlates of treatment failure
Verwijs et al. 2020 Am J Obstet Gynecol 222: 157.e1-157.e13
Impact of standard bacterial vaginosis treatment on the genital microbiota, immune milieu, and ex vivo human immunodeﬁciency virus susceptibility
Joag et al. 2019 Clin Infect Dis 68: 1675-1683
Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis
Cohen et al. 2020 NEJM 382: 1906-1915
Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis
Srinivasan et al. 2010 PLoS ONE 5: e10197
Treatment of male sexual partners of women with bacterial vaginosis: A randomized, double-blind, placebo-controlled trial
Schwebke et al. 2021 Clin Infect Dis 73: e672-e679

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