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Diclofenac & Gut microbiota
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The inhibition of bacterial beta-glucuronidase plays a protective role in mice against enteropathy, which is induced by certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as Diclofenac
In animals, E. coli beta-glucuronidase catalyzed the deconjugation of diclofenac acyl glucuronides in vitro, typical for Escherichia coli (E. coli).
LoGuidice et al. 2012 J Pharmacol Ex…