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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Immune checkpoint inhibitor-associated Colitis / Intestinal inflammation (ICIAC)

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Contents

Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events such as immune-mediated enterocolitis (IMC)
Groenewegen et al. 2023 Journal of Immunotherapy 46(6): 216-220

Intestinal inflammation is caused by excessive activation of IFN-gamma-producing CD4+ T cells.
There is also a depletion of peripherally induced regulatory T cells via Fcγ receptor signaling.
Lo et al. 2024 Science 383: 62-70

Enterocolitis is among the leading adverse events associated with immune checkpoint inhibitors (ICIs).
Grover et al. 2020 JOP 16: e933–e942

Increased representation of bacteria belongin…

References (Sources)

Fecal Microbiota Transplantation for Immune Checkpoint Inhibitor-Induced Colitis Is Safe and Contributes to Recovery: Two Case Reports
Groenewegen et al. 2023 Journal of Immunotherapy 46(6): 216-220
Immune Checkpoint Inhibitor–Mediated Diarrhea and Colitis: A Clinical Review
Gong et al. 2020 JOP 16: 453-461
Review
Intestinal microbiome analyses identify melanoma pts at risk for checkpoint-blockade-induced colitis
Dubin et al. 2016
Intestinal microbiota predicts lung cancer pts at risk of immune-related diarrhea
Liu et al. 2019b
Management Considerations for Immune Checkpoint Inhibitor Induced Enterocolitis Based on Management of Inﬂammatory Bowel Disease
Abu-Sbeih & Wang 2020
Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade–associated colitis via Fcγ receptors
Lo et al. 2024 Science 383: 62-70
Workup and Management of Immune Mediated Colitis in Pts Treated with Immune Checkpoint Inhibitors
Singh et al. 2020b

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