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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Indole-3-Aldehyde (IALD) / Indole-3-carboxaldehyde (I3A)

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Indole-3-Aldehyde (IAID) / Indole-3-carbaldehydeis also generated by Firmicutes phylum, such as Limosilactobacillus reuteri, L. johnsonii, L. acidophilus and L. murinus, via the Aromatic Amino Acid Transaminase (Pathway) and an Indolelactic acid dehydrogenase (ILDH)
Cervantes-Barragan et al. 2017 Science 357: 806-810

Indole-3-Aldehyde (IALD) / Indole-3-carboxaldehyde (I3A) has been found to engage the AhR and to balance mucosal reactivity via interleukin-22
Zelante et al. 2013 Immunity 39: 372–385

References (Sources)

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization
Vyhlidalova et al. 2020 Int. J. Mol. Sci. 21: 2614
Lactobacillus reuteri induces gut intraepithelial CD4 + CD8α + T cells
Cervantes-Barragan et al. 2017 Science 357: 806-810
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via IL-22
Zelante et al. 2013 Immunity 39: 372–385

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12/15/2025

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Indole-3-carbaldehyde - Wikipedia