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Under pathological conditions, the balance between the roles of kinases and phosphatases is disrupted. An increase in kinase activity and a decrease in phosphatase activity lead to tau hyperphosphorylation. As a result, the hyperphosphorylated tau protein misfolds, leading to more organized aggregates that eventually develop into neurofibrillary tangles within neurons. Neurofibrillary tangles impair regular axonal transport, disrupt synaptic plasticity, and induce cell death.
Neurofibrillary Tangles Result from [Tau Hyperphosphorylation](brain://yRt9VNcW5kC…