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Soluble forms of tau, particularly oligomeric tau, represent a major pathogenic subset of tau conformations
The microtubule-associated protein tau converts into beta-sheet-rich amyloid conformations, underlying pathology in over 25 related tauopathies .
Tau is a microtubule-associated protein (MAP) that promotes tubulin aggregation into microtubules, stabilizing the neuronal cytoskeleton to assure proper axonal transport, neurite outgrowth, and synaptic plasticity
Zhang et al. 2021j
Genetic factors like SNCA, PARK2, PARK7, [PINK1](brain://q4XqOg3zE0WCGZ_Q7ykQOg…