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Regenerating islet-derived proteins (Regs) are part of a larger group called the C‑type lectin fold superfamily. These proteins have special parts known as "C-type lectin-like" domains. They help cells in the liver, pancreas, stomach, and intestines grow and develop. Besides this, they also have important roles as antimicrobial peptides (AMPs), which means they help fight off harmful microbes. This is important for keeping our gut healthy. These molecules are involved in starting and worsening various gut-related diseases that involve inflammation. As AMPs, they help balance the gut's bacteria, protect the gut lining, and manage metabolism and energy. Specifically, [Regenerating islet-deriv…