meRfi®-GM
Aryl Hydrocarbon Receptor (AhR) & Cancer / Tumors
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Contents
When Kynurenine (Kyn) activates the Aryl hydrocarbon Receptor (AhR), it can lead to the expression of PD-1 on T cells that have moved into tumors, as well as PD-L1 on primary human lung cells and oral squamous cell cancers. This means that AhR activity might play a role in how the immune system's checkpoints are regulated, which could be important for developing cancer treatments.
AhR activity is linked to survival rates. Higher activity means lower survival in [lung cancer](brain://Jz-vYbomQkaHxyWzQyRBag/LungCancerLung…
References (Sources)
- Activation of the aryl hydrocarbon receptor leads to resistance to EGFR TKIs in non-small cell lung cancer by activating Src-mediated bypass signaling
- Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
- An aryl hydrocarbon receptor-mediated amplification loop that enforces cell migration in ER-/PR-/Her2- human breast cancer cells
- An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
- Aryl hydrocarbon receptor ligands in cancer: friend and foe
- Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
- Mixture effects of tryptophan intestinal microbial metabolites on aryl hydrocarbon receptor activity