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Sialic acid containing ligands are recognized by unique Siglecs (Sialic Acid-Binding-Type-Lectins)
Sialic acid-binding Siglec receptors, a family of immune-modulating receptors, have been identified as inhibitors of antitumor activity in myeloid cells, natural killer cells, and T cells.
Novel aspects of Sialoglycans / Sialylated glycans recognition by the Siglec-like domains of streptococcal SRR glycoproteins
Siglecs (Sialic Acid-Binding-Type-Lectins) are present on virtually all hematopoietic cells & usually negatively regulate Immune responses
Human T lymphocytes, including CD8 + T cells, were initially reported to express none or only low amounts of Siglecs (Sialic Acid-Binding-Type-Lectins)