Endothelial dysfunction & Septicemia / Sepsis

Endothelial cells are a crucial component of the vascular system, responsible for maintaining the integrity, tone, and patency of blood vessels. They play a vital role in various physiological processes, including hemostasis and inflammatory responses. While a certain level of endothelial dysfunction leading to increased vascular permeability is necessary for controlling local infections, excessive dysfunction can have detrimental effects.
Vincent et al. 2021 Expert Opinion on Therapeutic Targets 25(9): 733-748

In the context of sepsis, a severe systemic response to infection, endothelial dysfunction becomes a key player in the development of organ dysfunction and failure. This dysfunction contributes to dysregulated inflammation, vascular leakage, and abnormal coagulation, all of which are hallmark features…