meRfi®-GM
Beta-Catenin (Onkogen)
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Contents
Beta-catenin binds to the cytoplasmic part of cadherins (to the catenin-binding domain) and thus forms a bridge between cadherin and alfa-catenin. Beta-catenin also serves as a signaling molecule in the Wnt signaling pathway. It is transported into the cell nucleus and acts there as a component of a transcription factor. This is probably also the cause of increased beta-catenin concentrations in certain tumors.
Beta-catenin is a transcriptional co-activator that relies on T cell factor (TCF) …
References (Sources)
- Looking beyond the Wnt pathway for the deep nature of β‑catenin
- The expression and prognostic value of SOX2, β-catenin and survivin in esophageal squamous cell carcinoma
- The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
- Wnt/β-catenin signaling, disease, and emerging therapeutic modalities.