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Toxins cause excessive levels of Nitric Oxide (NO), thereby leading to the formation of reactive nitrogenous species along with ROS
NO generation occurs in two steps: first, NOS hydroxylates arginine to N ω -hydroxy-arginine (which remains largely bound to the enzyme); in a second step, NOS oxidizes [N ω -hydroxy-arginine](brain://bWQzl226g06ct5_uJAKC7…