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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Multiple sclerosis (MS) & T helper 17 cell (Th17)

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T helper 17 (Th17) cells have been identified as key players in the pathogenesis of Multiple sclerosis (MS) by promoting inflammation and demyelination in the CNS
Volpe et al. 2015 Mediators Inflamm. 2015: 475158

Multiple research studies have demonstrated the significant involvement of microRNAs (miRNAs) in the progression of Multiple Sclerosis (MS) and its response to treatment. Specifically, miRNAs have been found to play a crucial role in regulating the differentiation of T helper 17 cell (Th17), a subset of T helper cells known for their expression of RAR-related orphan receptor gamma/t (ROR-gamma/t) (NR1F3) and [Signal…

References (Sources)

Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis
Li et al. 2019a Aging (Albany NY) 11(13): 4463-4477
miR-141 and miR-200a, Revelation of New Possible Players in Modulation of Th17/Treg Differentiation and Pathogenesis of Multiple Sclerosis
Naghavian et al. 2015 PLoS One 10(5): e0124555
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity
Li et al. 2017i J Clin Invest 127: 3702-16
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting
Charabati et al. 2023 Cell 186(7): 1309
Review
T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon- β
Durelli et al. 2009 Ann. Neurol. 65: 499–509
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
Ja¨ger et al. 2009 J. Immunol. 183: 7169-7177
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GMCSF
El-Behi et al. 2011 Nat. Immunol. 12: 568-575

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