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CD8+ Cytotoxic T Lymphocytes (CTLs) have traditionally been studied in the context of pathogen or tumor clearance. However, recent reports have identified novel functions of CXCR5+ CD8+ T cells, which can home to Lymphoid follicles - a key site of antibody (Ab) production. CXCR5+ CD8+ T cell molecular phenotypes are associated with CD8+ T cells-mediated effector functions. These include distinct subsets that regulate antibody responses. One key marker, the coinhibitory molecule CD279 (Programmed cell death protein 1 (PD-1)), among others, distinguishes different CXCR5+ CD8+ T cell subsets.
CXCR5+ CD8+ T cells have cytotoxic capabilities similar to CD8+ Cytotoxic T Lymphocytes (CTLs)
see also:
C-X-C chemokine receptor type 5 (CXCR5)
Stem-like CD8+ T cells (CD8+SL)