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Gliomas have a high recurrence rate after surgical resection and are resistant to chemotherapy
Zeng et al. 2022a International Journal of Oncology 60: 76
Glioma tumors are one of the most devastating cancer types
Each glioma exhibits genetic, epigenetic, and environmental heterogeneity, resulting in extreme phenotypic heterogeneity at the cellular level. This intratumoral heterogeneity of gliomas and malignant cell state plasticity make the development of targeted therapies difficult.
Glioblastoma multiforme (GBM) / Glioblastoma is the most advanced stage with the worst prognosis
Gliomas are the most common primary brain tumor and one of…