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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Intranasal drug delivery

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Intranasal delivery has been shown to be a feasible method for targeting diseases, as demonstrated by several clinical and preclinical studies including

brain tumor
Bruinsmann et al. 2019 Molecules 24: 4312

metabolic disorders: Intranasal insulin restores metabolic parameters. It improves insulin sensitivity in rats with metabolic syndrome. Intranasal Leptin reduces appetite tested on rats with diet-induced obesity. Melanocyte-Stimulating Hormo…

References (Sources)

Anatomical and histological factors affecting intranasal drug and vaccine delivery
Gizurarson 2012 Curr Drug Deliv 9: 566-582
Intranasal delivery of BDNF rescues memory deﬁcits in AD11 mice and reduces brain microgliosis
Braschi et al. 2021 Aging Clin Exp Res 33: 1223-1238
Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome
Derkach et al. 2017 Bull Exp Biol Med 163: 184-189
Intranasal Leptin Reduces Appetite and Induces Weight Loss in Rats with Diet-Induced Obesity (DIO)
Schulz et al. 2012 Endocrinology 153: 143-153
Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials
Bruinsmann et al. 2019 Molecules 24: 4312
Review
The Melanocortin Melanocyte-Stimulating Hormone/ Adrenocorticotropin 4–10 Decreases Body Fat in Humans
Fehme et al. 2001 J Clin Endocrinol Metab 86: 1144-1148
Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
Hallschmid et al. 2008 Regul Pept 149: 79-83

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Intranasal drug delivery

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