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Alzheimer's Disease (AD) & Amyloid Pathology
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Contents
Current research suggests that neither amyloid plaques nor tau accumulation alone are responsible for neurodegeneration in Alzheimer's Disease (AD). Rather, it appears to be a complex interplay of various factors, with both amyloid and tau playing important roles. While tau pathology correlates better with the clinical course, amyloid might represent the initial trigger.
Alzheimer's Disease (AD) is characterized by early deposition of amyloid-b (Ab) plaques followed by pathological [tau](brain://Dbz8DkqMJk…
References (Sources)
- Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?
- Brain-Gut-Microbiota Axis in Alzheimer’s DiseaseReview
- Neuroinflammation and Alzheimer’s disease: implications for microglial activation
- Probiotics for Alzheimer’s Disease: A Systematic Review
- Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide
- Systemic inflammation and disease progression in Alzheimer disease.
- Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease