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Current research suggests that neither amyloid plaques nor tau accumulation alone are responsible for neurodegeneration in Alzheimer's Disease (AD). Rather, it appears to be a complex interplay of various factors, with both amyloid and tau playing important roles. While tau pathology correlates better with the clinical course, amyloid might represent the initial trigger.
Alzheimer's Disease (AD) is characterized by early deposition of amyloid-b (Ab) plaques followed by pathological [tau](brain://Dbz8DkqMJk…