meRfi®-GM
vomeronasal receptor Vmn2r26
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Contents
Mechanistically, Vmn2r26 engaged with N-undecanoylglycine (N-C11-G) activated G-protein-coupled receptor-phospholipase C gamma2 (GPCR-PLC-gamma 2)-Ca2+ signaling axis, which initiated prostaglandin D2 (PGD2)) production.
Xiong et al. 2022b Immunity 55: 686-700.e7
Moreover, Vmn2r26 signaling also promoted SpiB transcription factor expression, responsible for Tuft-2 cell development and expansion in response to bacterial challe…