Loading…

Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Adiposity / Obesity & Farnesoid X Receptor (FXR / NR1H4)

Welcome to meRfi-GM!

Please register to continue your trial period!

meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

Microbiota induces diet-induced adiposity / obesity through Farnesoid X receptor (FXR / NR1H4) signal transduction
Li et al. 2013a
Jiang et al. 2015a
Parseus et al. 2016

Ligands for TGR5 stimulate incretin release in vitro and decrease blood glucose levels in vivo and thus hold promise for treating obesity and type 2 diabetes. [Bi…

Bile acids induce energy expenditure by promoting intracellular thyroid hormoneactivation
Watanabe et al. 2006 Nature 439: 484–489
Bile-acid-activated receptors: Targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
Fiorucci et al. 2009 Trends Pharm. Sci. 30: 570-580
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Jiang et al. 2015a
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Jiang et al. 2015 Nat Commun 6: 10166
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Li et al. 2013a
Microbiota-induced obesity requires farnesoid X receptor
Parseus et al. 2016
Role of Bile Acids in the Regulation of Food Intake, and Their Dysregulation in Metabolic Disease
Xie et al. 2021a
Review

12/16/2025