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A niche is a spatial organization in which the microbiome interacts with the host (microbiome-host niche), e.g., with the host's immune system
The interaction is via secondary metabolites, foreign molecular patterns (MAMPs, PAMPs), and antigens.
The residence time of microbial stimuli in discrete spatial niches determines the strength and duration of host stimulation
Graham & Xavier 2023 Trends in Immu…