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Niches
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Contents
A niche is a spatial organization in which the microbiome interacts with the host (microbiome-host niche), e.g., with the host's immune system
The interaction is via secondary metabolites, foreign molecular patterns (MAMPs, PAMPs), and antigens.
The residence time of microbial stimuli in discrete spatial niches determines the strength and duration of host stimulation
Graham & Xavier 2023 Trends in Immu…
References (Sources)
- Analysis of transcriptionally active bacteria throughout the gastrointestinal tract of healthy individuals
- Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque
- Conditioning of the immune system by the microbiome
- Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis
- Gut biogeography of the bacterial microbiota
- Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease
- The gut microbiome: connecting spatial organization to function