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Composition of the Blood Brain Barrier (BBB)
The BBB consists of highly specialized endothelial cells that express tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and Claudin-1 / CLDN1, -3, and -5.
In addition to this endothelial barrier, the BBB also consists of pericytes and astrocytic end-feet surrounding the endothelial cells
Zhao et al. 2015 Cell 163(5): 1…