meRfi®-GM
Blood Brain Barrier (BBB)
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Composition of the Blood Brain Barrier (BBB)
The BBB consists of highly specialized endothelial cells that express tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and Claudin-1 / CLDN1, -3, and -5.
In addition to this endothelial barrier, the BBB also consists of pericytes and astrocytic end-feet surrounding the endothelial cells
Zhao et al. 2015 Cell 163(5): 1…
References (Sources)
- Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders
- Establishment and dysfunction of the blood-brain barrier
- Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
- MyD88 Deficiency, but Not Gut Microbiota Depletion, Is Sufficient to Modulate the Blood–Brain Barrier Function in the Mediobasal Hypothalamus
- New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains
- Research progress in brain-targeted nasal drug delivery
- Therapy and prophylaxis of brain metastases