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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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D cells are located have the luminal receptors LPAR5 and GPRC6A, and release somatostatin. They inhibit gastrin release in the stomach and modulate insulin release in the pancreas
Furness et al. 2013a Nature Reviews Gastroenterology & Hepatology 10: 729-740

Named for similarity to pancreatic D cell. The identifying hormone (historically) is

Somatostatin

Examples of colocalization of hormones and/or their gene transcripts (most of recent data is from mouse):

GIP (some expressing)

Habib et al. 2012 Endocrinology 153: …

References (Sources)

A Focus on Enterochromafﬁn Cells among the Enteroendocrine Cells: Localization, Morphology, and Role
Rezzani et al. 2022 Int. J. Mol. Sci. 23: 3758
Review
Diversity of enteroendocrine cells investigated at cellular and subcellular levels: the need for a new classification scheme.
Fothergill & Furness 2018 Histochem Cell Biol 150(6): 693-702
Review
Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry
Habib et al. 2012 Endocrinology 153: 3054-3065
The gut as a sensory organ
Furness et al. 2013a Nature Reviews Gastroenterology & Hepatology 10: 729-740
Review

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12/16/2025

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