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Eosinophils
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Eosinophils are multi-functional granulocytes commonly identified as effector cells mobilized during type II immune responses
The largest population of eosinophils resides in the gastrointestinal (GI) tract. They are recruited to the gut during late gestation and early life independent of the microbiota
[Jiménez-Saiz et al. 2020 Front. Im…
References (Sources)
- Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis
- Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.
- Fundamental signals that regulate eosinophil homing to the gastrointestinal tract
- Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
- Microbiota-regulated IL-25 increases eosinophil number to provide protection during Clostridium difficile infection
- Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
- Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization