Chemokine (C-X-C motif) ligand 8 (CXCL8) / Interleukin-8 (IL-8)

Aliases: CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8

CXCL8 / Interleukin-8 (IL-8) is produced by

• Monocytes


• Macrophages


• Fibroblasts


• Epithelial cells


• Endothelial Cells / Endothelium
  Murphy 2022 W.W. Norton & Company ISBN 978-0-393-68093-5

CXCL8 / Interleukin-8 (IL-8) acts on

• C-X-C chemokine receptor type 1 (CXCR1) / Interleukin 8 receptor alfa (IL-8R alfa)


• C-X-C chemokine receptor type 2 (CXCR2) / Interleukin 8 receptor beta (IL-8R beta)
  Murphy 2022 W.W. Norton & Company ISBN 978-0-393-68093-5

Attracted cells are

• Neutrophils


• Naive T cells
  Murphy 2022 W.W. Norton & Company ISBN 978-0-393-68093-5

Major effects are

• Mobilizes , activates, degranulates neutrophils


• Angiogenesis
  Murphy 2022 W.W. Norton & Company ISBN 978-0-393-68093-5

Probiotics were also found to inhibit cytokine Interleukin-8 (IL-8) / CXCL8 in epithelial cells and keratinocytes, suggesting immunomodulatory activities
Goodarzi et al. 2020