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Studies suggest that butyrate can suppress the differentiation and expansion of tuft cells. This effect is mediated through the inhibition of histone deacetylase 3 (HDAC3), which is crucial for tuft cell homeostasis. Butyrate reduces tuft cell numbers and diminishes their hyperplasia in response to certain cytokines like IL-13
see also:
Enterocytes / Intestinal Epithelial Cells (IECs) & Histone deacetylase 3 (HDAC3)
[Gut microbiota & Histone deacetylase…